NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells

NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells

Summary: The mechanism by which redox metabolism regulates the fates of acute myeloid leukemia (AML) cells remains largely unknown. Using a highly sensitive, genetically encoded fluorescent sensor of nicotinamide adenine dinucleotide phosphate (NADPH), iNap1, we find three heterogeneous subpopulatio...

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Bibliographic Details
Main Authors:	Chiqi Chen, Xiaoyun Lai, Yaping Zhang, Li Xie, Zhuo Yu, Sijia Dan, Yu Jiang, Weicai Chen, Ligen Liu, Yi Yang, Dan Huang, Yuzheng Zhao, Junke Zheng
Format:	Article
Language:	English
Published:	Elsevier 2022-04-01
Series:	Cell Reports
Subjects:	NADPH metabolism metabolic sensor acute myeloid leukemia leukemia-initiating cells endosteal niche vascular niche
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124722003552

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