MAPKs/AP-1, not NF-κB, is responsible for MCP-1 production in TNF-α-activated adipocytes

MAPKs/AP-1, not NF-κB, is responsible for MCP-1 production in TNF-α-activated adipocytes

Obesity is associated with the infiltration of monocytes/macrophages into adipose tissue in which MCP-1 plays a crucial role. But the regulatory mechanism of MCP-1 expression in adipocytes is not well defined. Our results demonstrated that TNF-α induced abundant MCP-1 production in adipocytes, inclu...

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Bibliographic Details
Main Authors: Xiaoyu Zhang, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Zhenlu Xu, Ximeng Li, Yuan Gao, Yun Qi
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Adipocyte
Subjects:
Obesity
adipocyte
MCP-1
MAPKs/AP-1
NF-κB
Online Access:https://www.tandfonline.com/doi/10.1080/21623945.2022.2107786

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