Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14344-7 |
| _version_ | 1819039730708250624 |
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| author | Phuong-Uyen C. Dinh Dipti Paudel Hayden Brochu Kristen D. Popowski M. Cyndell Gracieux Jhon Cores Ke Huang M. Taylor Hensley Erin Harrell Adam C. Vandergriff Arianna K. George Raina T. Barrio Shiqi Hu Tyler A. Allen Kevin Blackburn Thomas G. Caranasos Xinxia Peng Lauren V. Schnabel Kenneth B. Adler Leonard J. Lobo Michael B. Goshe Ke Cheng |
| author_facet | Phuong-Uyen C. Dinh Dipti Paudel Hayden Brochu Kristen D. Popowski M. Cyndell Gracieux Jhon Cores Ke Huang M. Taylor Hensley Erin Harrell Adam C. Vandergriff Arianna K. George Raina T. Barrio Shiqi Hu Tyler A. Allen Kevin Blackburn Thomas G. Caranasos Xinxia Peng Lauren V. Schnabel Kenneth B. Adler Leonard J. Lobo Michael B. Goshe Ke Cheng |
| author_sort | Phuong-Uyen C. Dinh |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. |
| first_indexed | 2024-12-21T08:57:51Z |
| format | Article |
| id | doaj.art-4496cdf678834d70ba8a9b30f7098a55 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T08:57:51Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4496cdf678834d70ba8a9b30f7098a552022-12-21T19:09:31ZengNature PortfolioNature Communications2041-17232020-02-0111111410.1038/s41467-020-14344-7Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosisPhuong-Uyen C. Dinh0Dipti Paudel1Hayden Brochu2Kristen D. Popowski3M. Cyndell Gracieux4Jhon Cores5Ke Huang6M. Taylor Hensley7Erin Harrell8Adam C. Vandergriff9Arianna K. George10Raina T. Barrio11Shiqi Hu12Tyler A. Allen13Kevin Blackburn14Thomas G. Caranasos15Xinxia Peng16Lauren V. Schnabel17Kenneth B. Adler18Leonard J. Lobo19Michael B. Goshe20Ke Cheng21Department of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular and Structural Biochemistry, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular and Structural Biochemistry, North Carolina State UniversityComparative Medicine Institute, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State UniversityDepartment of Molecular and Structural Biochemistry, North Carolina State UniversityDepartment of Biological Sciences, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDepartment of Molecular and Structural Biochemistry, North Carolina State UniversityDivision of Cardiothoracic Surgery, University of North Carolina at Chapel HillDepartment of Molecular Biomedical Sciences, North Carolina State UniversityComparative Medicine Institute, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel HillDepartment of Molecular and Structural Biochemistry, North Carolina State UniversityDepartment of Molecular Biomedical Sciences, North Carolina State UniversityIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.https://doi.org/10.1038/s41467-020-14344-7 |
| spellingShingle | Phuong-Uyen C. Dinh Dipti Paudel Hayden Brochu Kristen D. Popowski M. Cyndell Gracieux Jhon Cores Ke Huang M. Taylor Hensley Erin Harrell Adam C. Vandergriff Arianna K. George Raina T. Barrio Shiqi Hu Tyler A. Allen Kevin Blackburn Thomas G. Caranasos Xinxia Peng Lauren V. Schnabel Kenneth B. Adler Leonard J. Lobo Michael B. Goshe Ke Cheng Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis Nature Communications |
| title | Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis |
| title_full | Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis |
| title_fullStr | Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis |
| title_full_unstemmed | Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis |
| title_short | Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis |
| title_sort | inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis |
| url | https://doi.org/10.1038/s41467-020-14344-7 |
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