Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Abstract Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses. In this randomized trial (Clinicaltrials.gov: NCT03722589), sera pre- and post-vaccination with quadrivalent inacti...

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Bibliographic Details
Main Authors: Feng Liu, F. Liaini Gross, Sneha Joshi, Manjusha Gaglani, Allison L. Naleway, Kempapura Murthy, Holly C. Groom, Meredith G. Wesley, Laura J. Edwards, Lauren Grant, Sara S. Kim, Suryaprakash Sambhara, Shivaprakash Gangappa, Terrence Tumpey, Mark G. Thompson, Alicia M. Fry, Brendan Flannery, Fatimah S. Dawood, Min Z. Levine
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44551-x

Internet

https://doi.org/10.1038/s41467-023-44551-x

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