Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes

Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes

Mutations of H-Ras, a member of the RAS family, are preferentially found in cutaneous squamous cell carcinomas (SCCs). H-Ras has been reported to induce autophagy, which plays an essential role in tissue homeostasis in multiple types of cancer cells and in fibroblasts, however, the potential role of...

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Bibliographic Details
Main Authors: Shuangshuang Wang, Hua Qian, Liwei Zhang, Panpan Liu, Dexuan Zhuang, Qun Zhang, Fuxiang Bai, Zhihong Wang, Yonggan Yan, Jing Guo, Jun Huang, Xunwei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
H-Ras
calcineurin
NFATc1
autophagy
keratinocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.720111/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.720111/full

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