Differential Regulation of Bilastine Affinity for Human Histamine H<sub>1</sub> Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy

Differential Regulation of Bilastine Affinity for Human Histamine H<sub>1</sub> Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy

Bilastine, a zwitterionic second-generation antihistamine containing a carboxyl group, has higher selectivity for H<sub>1</sub> receptors than first-generation antihistamines. Ligand-receptor docking simulations have suggested that the electrostatic interaction between the carboxyl group...

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Bibliographic Details
Main Authors: Hayato Akimoto, Minoru Sugihara, Shigeru Hishinuma
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
affinity
antihistamine
bilastine
enthalpy
entropy
histamine H<sub>1</sub> receptor
Online Access:https://www.mdpi.com/1422-0067/22/4/1655

Internet

https://www.mdpi.com/1422-0067/22/4/1655

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