Central role of Prominin-1 in lipid rafts during liver regeneration
Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33969-4 |
| _version_ | 1811249980953853952 |
|---|---|
| author | Myeong-Suk Bahn Dong-Min Yu Myoungwoo Lee Sung-Je Jo Ji-Won Lee Ho-Chul Kim Hyun Lee Hong Lim Kim Arum Kim Jeong-Ho Hong Jun Seok Kim Seung-Hoi Koo Jae-Seon Lee Young-Gyu Ko |
| author_facet | Myeong-Suk Bahn Dong-Min Yu Myoungwoo Lee Sung-Je Jo Ji-Won Lee Ho-Chul Kim Hyun Lee Hong Lim Kim Arum Kim Jeong-Ho Hong Jun Seok Kim Seung-Hoi Koo Jae-Seon Lee Young-Gyu Ko |
| author_sort | Myeong-Suk Bahn |
| collection | DOAJ |
| description | Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3. |
| first_indexed | 2024-04-12T15:57:01Z |
| format | Article |
| id | doaj.art-44a2b730a3d24d5aa6b5b8449e0f3f16 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:57:01Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-44a2b730a3d24d5aa6b5b8449e0f3f162022-12-22T03:26:20ZengNature PortfolioNature Communications2041-17232022-10-0113111610.1038/s41467-022-33969-4Central role of Prominin-1 in lipid rafts during liver regenerationMyeong-Suk Bahn0Dong-Min Yu1Myoungwoo Lee2Sung-Je Jo3Ji-Won Lee4Ho-Chul Kim5Hyun Lee6Hong Lim Kim7Arum Kim8Jeong-Ho Hong9Jun Seok Kim10Seung-Hoi Koo11Jae-Seon Lee12Young-Gyu Ko13Division of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityLaboratory of Electron Microscope, Integrative Research Support Center, College of Medicine, The Catholic University of KoreaDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversityResearch Center for Controlling Intercellular Communication, College of Medicine, Inha UniversityDivision of Life Sciences, Korea UniversityBahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3.https://doi.org/10.1038/s41467-022-33969-4 |
| spellingShingle | Myeong-Suk Bahn Dong-Min Yu Myoungwoo Lee Sung-Je Jo Ji-Won Lee Ho-Chul Kim Hyun Lee Hong Lim Kim Arum Kim Jeong-Ho Hong Jun Seok Kim Seung-Hoi Koo Jae-Seon Lee Young-Gyu Ko Central role of Prominin-1 in lipid rafts during liver regeneration Nature Communications |
| title | Central role of Prominin-1 in lipid rafts during liver regeneration |
| title_full | Central role of Prominin-1 in lipid rafts during liver regeneration |
| title_fullStr | Central role of Prominin-1 in lipid rafts during liver regeneration |
| title_full_unstemmed | Central role of Prominin-1 in lipid rafts during liver regeneration |
| title_short | Central role of Prominin-1 in lipid rafts during liver regeneration |
| title_sort | central role of prominin 1 in lipid rafts during liver regeneration |
| url | https://doi.org/10.1038/s41467-022-33969-4 |
| work_keys_str_mv | AT myeongsukbahn centralroleofprominin1inlipidraftsduringliverregeneration AT dongminyu centralroleofprominin1inlipidraftsduringliverregeneration AT myoungwoolee centralroleofprominin1inlipidraftsduringliverregeneration AT sungjejo centralroleofprominin1inlipidraftsduringliverregeneration AT jiwonlee centralroleofprominin1inlipidraftsduringliverregeneration AT hochulkim centralroleofprominin1inlipidraftsduringliverregeneration AT hyunlee centralroleofprominin1inlipidraftsduringliverregeneration AT honglimkim centralroleofprominin1inlipidraftsduringliverregeneration AT arumkim centralroleofprominin1inlipidraftsduringliverregeneration AT jeonghohong centralroleofprominin1inlipidraftsduringliverregeneration AT junseokkim centralroleofprominin1inlipidraftsduringliverregeneration AT seunghoikoo centralroleofprominin1inlipidraftsduringliverregeneration AT jaeseonlee centralroleofprominin1inlipidraftsduringliverregeneration AT younggyuko centralroleofprominin1inlipidraftsduringliverregeneration |