Silica Nanoparticle Internalization Improves Chemotactic Behaviour of Human Mesenchymal Stem Cells Acting on the SDF1α/CXCR4 Axis

Silica Nanoparticle Internalization Improves Chemotactic Behaviour of Human Mesenchymal Stem Cells Acting on the SDF1α/CXCR4 Axis

Human mesenchymal stem cell (hMSC)-based therapy is an emerging resource in regenerative medicine. Despite the innate ability of hMSCs to migrate to sites of injury, homing of infused hMSCs to the target tissue is inefficient. It was shown that silica nanoparticles (SiO<sub>2</sub>-NPs),...

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Bibliographic Details
Main Authors: Emanuela Vitale, Daniela Rossin, Sadia Perveen, Ivana Miletto, Marco Lo Iacono, Raffaella Rastaldo, Claudia Giachino
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
human mesenchymal stem cells
regenerative medicine
silica nanoparticles
hMSC homing
SDF1α/CXCR4 axis
tissue injury
Online Access:https://www.mdpi.com/2227-9059/10/2/336

Internet

https://www.mdpi.com/2227-9059/10/2/336

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