Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies

Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies

Abstract Background Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a role in tumor growth and treatment resistance with multimodal PET and MRI...

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Bibliographic Details
Main Authors: Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel, Myriam Bernaudin
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:EJNMMI Research
Subjects:
Brain metastasis
Lung cancer
Hypoxia
HIF
Oxidative stress
Cu-ATSM
Online Access:https://doi.org/10.1186/s13550-023-01052-8

Internet

https://doi.org/10.1186/s13550-023-01052-8

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