Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.

Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.

Rapidly growing tumors require efficient means to allow them to adapt to fluctuating microenvironments consisting of hypoxia, nutrient deprivation, and acidosis. The unfolded protein response (UPR) represents a defense mechanism allowing cells to respond to these adverse conditions. The chaperone pr...

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Bibliographic Details
Main Authors: Antony Prabhu, Bhaswati Sarcar, Soumen Kahali, Yuan Shan, Prakash Chinnaiyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527517?pdf=render

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http://europepmc.org/articles/PMC3527517?pdf=render

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