Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

ABSTRACTThe gut microbiota affects hepatic drug metabolism. However, gut microbial factors modulating hepatic drug metabolism are largely unknown. In this study, using a mouse model of acetaminophen (APAP)-induced hepatotoxicity, we identified a gut bacterial metabolite that controls the hepatic exp...

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Bibliographic Details
Main Authors: Sungjoon Cho, Xiaotong Yang, Kyoung-Jae Won, Vanessa A. Leone, Eugene B. Chang, Grace Guzman, Yeonju Ko, Ok-Nam Bae, Hyunwoo Lee, Hyunyoung Jeong
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Mouse gut microbiota
metabolomics
CYP2E1
acetaminophen
hepatotoxicity
liver injury
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2231590

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2023.2231590

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