Distinct patterns of auto-reactive antibodies associated with organ-specific immune-related adverse events

Distinct patterns of auto-reactive antibodies associated with organ-specific immune-related adverse events

The roles of preexisting auto-reactive antibodies in immune-related adverse events (irAEs) associated with immune checkpoint inhibitor therapy are not well defined. Here, we analyzed plasma samples longitudinally collected at predefined time points and at the time of irAEs from 58 patients with immu...

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Bibliographic Details
Main Authors: Mehmet Altan, Quan-Zhen Li, Qi Wang, Natalie I. Vokes, Ajay Sheshadri, Jianjun Gao, Chengsong Zhu, Hai T. Tran, Saumil Gandhi, Mara B. Antonoff, Stephen Swisher, Jing Wang, Lauren A. Byers, Noha Abdel-Wahab, Maria C. Franco-Vega, Yinghong Wang, J. Jack Lee, Jianjun Zhang, John V. Heymach
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
NSCLC
auto-reactive antibodies
immune related adverse events
immune checkpoint inhibitor
pneumonitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1322818/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1322818/full

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