Pectolinarigenin Improves Oxidative Stress and Apoptosis in Mouse NSC-34 Motor Neuron Cell Lines Induced by C9-ALS-Associated Proline–Arginine Dipeptide Repeat Proteins by Enhancing Mitochondrial Fusion Mediated via the SIRT3/OPA1 Axis
Amyotrophic lateral sclerosis (ALS) is considered a fatal progressive degeneration of motor neurons (MN) caused by oxidative stress and mitochondrial dysfunction. There are currently no treatments available. The most common inherited form of ALS is the <i>C9orf72</i> mutation (C9-ALS). T...
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Format: | Article |
Language: | English |
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MDPI AG
2023-11-01
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Series: | Antioxidants |
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Online Access: | https://www.mdpi.com/2076-3921/12/11/2008 |