Antidiabetic activity of a Flavonoid-Rich extract from flowers of Wisteria sinensis in type 2 diabetic mice via activation of the IRS-1/PI3K/Akt/GLUT4 pathway

Antidiabetic activity of a Flavonoid-Rich extract from flowers of Wisteria sinensis in type 2 diabetic mice via activation of the IRS-1/PI3K/Akt/GLUT4 pathway

The present study aimed to investigate anti-diabetic activities of a flavonoid-rich extract from Wisteria sinensis (WS-FRE). In vitro, WS-FRE significantly promote the translocation of GLUT4 (Glucose transporter 4) to the plasma membrane. Mechanisms analysis revealed that WS-FRE enhanced glucose upt...

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Bibliographic Details
Main Authors: Yun Huang, Tongxi Zhou, Yirui Zhang, Huiqi Huang, Yuanren Ma, Chaoqun Wu, Qiang Wang, Qinxiong Lin, Xinzhou Yang, Kejian Pang
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Journal of Functional Foods
Subjects:
Type 2 diabetes mellitus
Wisteria sinensis
GLUT4
PI3K/Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620305624

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http://www.sciencedirect.com/science/article/pii/S1756464620305624

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