Cilostazol promotes blood vessel formation and bone regeneration in a murine non-union model

Cilostazol promotes blood vessel formation and bone regeneration in a murine non-union model

Non-unions represent a major complication in trauma and orthopedic surgery. Many factors contribute to bone regeneration, out of which an adequate vascularization has been recognized as crucial. The phosphodiesterase-3 (PDE-3) inhibitor cilostazol has been shown to exert pro-angiogenic and pro-osteo...

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Bibliographic Details
Main Authors: Maximilian M. Menger, Michelle Bleimehl, David Bauer, Claudia Scheuer, Sandra Hans, Dominik Saul, Sabrina Ehnert, Michael D. Menger, Tina Histing, Matthias W. Laschke
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Non-union
Cilostazol
Segmental defect
Bone regeneration
Fracture healing
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223014956

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http://www.sciencedirect.com/science/article/pii/S0753332223014956

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