Characterisation of the salmon cystic fibrosis transmembrane conductance regulator protein for structural studies

Characterisation of the salmon cystic fibrosis transmembrane conductance regulator protein for structural studies

The cystic fibrosis transmembrane conductance regulator protein (CFTR) is a chloride channel highly expressed in the gills of Salmo salar, with a role in osmoregulation. It shares 60% identity with the human CFTR channel, mutations to which can cause the common genetic disorder cystic fibrosis CF. T...

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Bibliographic Details
Main Authors: Naomi L. Pollock, Oscar Moran, Debora Baroni, Olga Zegarra-Moran, Robert C. Ford
Format: Article
Language:English
Published: AIMS Press 2014-11-01
Series:AIMS Molecular Science
Subjects:
CFTR
CFTR purification
salmon
osmoregulation
Saccharomyces cerevisiae
heterologous overexpression
membrane protein purification
cryo-electron microscopy
small-angle X-ray scattering (SAXS)
Online Access:http://www.aimspress.com/article/10.3934/molsci.2014.4.141/fulltext.html

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http://www.aimspress.com/article/10.3934/molsci.2014.4.141/fulltext.html

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