Inflammasome-Independent NALP3 Contributes to High-Salt Induced Endothelial Dysfunction

Inflammasome-Independent NALP3 Contributes to High-Salt Induced Endothelial Dysfunction

Backgrounds and Aims: Na+ is an important nutrient and its intake, mainly from salt (NaCl), is essential for normal physiological function. However, high salt intake may lead to vascular injury, independent of a rise in blood pressure (BP). Canonical NALP3 inflammasome activation is a caspase-1 medi...

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Bibliographic Details
Main Authors: Hui Fu, Ji-Kuai Chen, Wen-Jie Lu, Yu-Jie Jiang, Yuan-Yuan Wang, Dong-Jie Li, Fu-Ming Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
high salt intake
endothelial-dependent relaxation
angiogenic function
NALP3
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00968/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00968/full

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