Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC) homeostasis; however, the understanding of how different cell populations contribute to this process is limited. Here, we utilized single-cell RNA sequencing to provide insight into cellular composition changes...

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Bibliographic Details
Main Authors: Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna Kwapiszewska
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-10-01
Series:JCI Insight
Subjects:
Pulmonology
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.153471

Internet

https://doi.org/10.1172/jci.insight.153471

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