Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

BackgroundExcessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, is one of the essential modulators of host res...

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Bibliographic Details
Main Authors: Jan D. Zemtsovski, Srinu Tumpara, Sonja Schmidt, Vijith Vijayan, Andreas Klos, Robert Laudeley, Julia Held, Stephan Immenschuh, Florian M. Wurm, Tobias Welte, Hermann Haller, Sabina Janciauskiene, Nelli Shushakova
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
mice
sepsis
alpha1-antitrypsin
free heme
inflammation
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368040/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368040/full

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