The Hydropathy Index of the HCDR3 Region of the B-Cell Receptor Identifies Two Subgroups of IGHV-Mutated Chronic Lymphocytic Leukemia Patients With Distinct Outcome

The Hydropathy Index of the HCDR3 Region of the B-Cell Receptor Identifies Two Subgroups of IGHV-Mutated Chronic Lymphocytic Leukemia Patients With Distinct Outcome

The HCDR3 sequences of the B-cell receptor (BCR) undergo constraints in length, amino acid use, and charge during maturation of B-cell precursors and after antigen encounter, leading to BCR and antibodies with high affinity to specific antigens. Chronic lymphocytic leukemia consists of an expansion...

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Bibliographic Details
Main Authors: Arancha Rodríguez-Caballero, Blanca Fuentes Herrero, Guillermo Oliva Ariza, Ignacio Criado, Miguel Alcoceba, Carlos Prieto, María Pérez Caro, Andrés C. García-Montero, Marcos González Díaz, Francesco Forconi, Ana Bela Sarmento-Ribeiro, Julia Almeida, Alberto Orfao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
hydropathy index
neutral HCDR3
negatively charged HCDR3
mutated CLL (M-CLL)
disease progression
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.723722/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.723722/full

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