TLR2 and TLR4 mediate differential responses to limb ischemia through MyD88-dependent and independent pathways.

TLR2 and TLR4 mediate differential responses to limb ischemia through MyD88-dependent and independent pathways.

The danger signal HMGB1 is released from ischemic myocytes, and mediates angiogenesis in the setting of hindlimb ischemia. HMGB1 is a ligand for innate immune receptors TLR2 and TLR4. While both TLR2 and TLR4 signal through myeloid differentiation factor 88 (MyD88), TLR4 also uniquely signals throug...

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Bibliographic Details
Main Authors: Ulka Sachdev, Xiangdong Cui, Ryan McEnaney, Tian Wang, Kelly Benabou, Edith Tzeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3510193?pdf=render

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http://europepmc.org/articles/PMC3510193?pdf=render

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