Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress

Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress

Vascular calcification (VC) is a common pathophysiological process of chronic kidney disease (CKD). Sirtuin 3 (Sirt3), a major NAD<sup>+</sup>-dependent protein deacetylase predominantly in mitochondria, is involved in the pathogenesis of VC. We previously reported that intermedin (IMD)...

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Bibliographic Details
Main Authors: Shi-Meng Liu, Ya-Rong Zhang, Yao Chen, Deng-Ren Ji, Jie Zhao, Su Fu, Mo-Zhi Jia, Yan-Rong Yu, Chao-Shu Tang, Wei Huang, Ye-Bo Zhou, Yong-Fen Qi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
intermedin
vascular calcification
sirtuin 3
mitochondrial oxidative stress
chronic kidney disease
Online Access:https://www.mdpi.com/1424-8247/15/10/1224

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https://www.mdpi.com/1424-8247/15/10/1224

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