Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

Abstract Background Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. Methods Five commercially available parallel sequencing assays were evaluated for their ability to detect gene fusions in eight cell lin...

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Bibliographic Details
Main Authors: Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Medical Genomics
Subjects:
NGS
FISH
Gene fusion
DNA-Seq
RNA-seq
Online Access:https://doi.org/10.1186/s12920-021-00909-y

Internet

https://doi.org/10.1186/s12920-021-00909-y

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