Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

<h4>Background</h4>The role of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in the regulation of energy metabolism and immune system by locally reactivating glucocorticoids has been extensively studied. Experiments determining initial rates of enzyme activity revealed that 11...

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Bibliographic Details
Main Authors: Lyubomir G Nashev, Charlie Chandsawangbhuwana, Zoltan Balazs, Atanas G Atanasov, Bernhard Dick, Felix J Frey, Michael E Baker, Alex Odermatt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0000561

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https://doi.org/10.1371/journal.pone.0000561

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