Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis

Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis

Abstract Background The evolutionarily conserved protein FBXO9 acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase and is implicated in cancer, exhibiting either tumor-suppressive or oncogenic effects depending on the specific tumor type. However, their role in lung cancer metas...

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Bibliographic Details
Main Authors: Liang Liu, Xiaodong Chen, Leilei Wu, Kaizong Huang, Zhenyi Wang, Yaolin Zheng, Cheng Zheng, Zhenshan Zhang, Jiayan Chen, Jiaming Wei, Song Chen, Weilin Jin, Jinfei Chen, Dongping Wei, Yaping Xu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Experimental Hematology & Oncology
Subjects:
FBXO9
Ubiquitination
V-ATPase assembly
Migration
Cancer stemness
Metastasis
Online Access:https://doi.org/10.1186/s40164-024-00497-4

Internet

https://doi.org/10.1186/s40164-024-00497-4

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