Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing

Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing

Abstract Introduction Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellular machinery controlling this process (spliceosome components and splicing factors) in hepatocellular carcinoma (HCC) is poorly known. This study aimed to comprehe...

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Bibliographic Details
Main Authors: Juan L. López‐Cánovas, Natalia Hermán‐Sánchez, Maria Trinidad Moreno‐Montilla, Mercedes del Rio‐Moreno, Emilia Alors‐Perez, Marina E. Sánchez‐Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de laMata, Justo P. Castaño, Manuel Rodriguez‐Perálvarez, Raúl M. Luque, Manuel D. Gahete
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Clinical and Translational Medicine
Subjects:
FGF19
liver cancer
preclinical model
splicing machinery
Online Access:https://doi.org/10.1002/ctm2.1102

Internet

https://doi.org/10.1002/ctm2.1102

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