The Prp19 complex directly functions in mitotic spindle assembly.

The Prp19 complex directly functions in mitotic spindle assembly.

The conserved Prp19 (pre-RNA processing 19) complex is required for pre-mRNA splicing in eukaryotic nuclei. Recent RNAi screens indicated that knockdown of Prp19 complex subunits strongly delays cell proliferation. Here we show that knockdown of the smallest subunit, BCAS2/Spf27, destabilizes the en...

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Bibliographic Details
Main Authors: Jennifer C Hofmann, Justus Tegha-Dunghu, Stefanie Dräger, Cindy L Will, Reinhard Lührmann, Oliver J Gruss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3777999?pdf=render

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http://europepmc.org/articles/PMC3777999?pdf=render

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