Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach

Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach

Glucokinase activators are considered as new therapeutic arsenals that bind to the allosteric activator sites of glucokinase enzymes, thereby maximizing its catalytic rate and increasing its affinity to glucose. This study was designed to identify potent glucokinase activators from prenylated flavon...

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Bibliographic Details
Main Authors: Kolade Olatubosun Faloye, Boris Davy Bekono, Emmanuel Gabriel Fakola, Marcus Durojaye Ayoola, Oyenike Idayat Bello, Oluwabukunmi Grace Olajubutu, Onikepe Deborah Owoseeni, Shafi Mahmud, Mohammed Alqarni, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Ahmad J. Obaidullah
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
glucokinase activators
prenylated flavonoids
molecular docking
molecular dynamics simulation
density functional theory
ADMET
Online Access:https://www.mdpi.com/1420-3049/26/23/7211

Internet

https://www.mdpi.com/1420-3049/26/23/7211

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