Spatial heterogeneity and organization of tumor mutation burden with immune infiltrates within tumors based on whole slide images correlated with patient survival in bladder cancer

Spatial heterogeneity and organization of tumor mutation burden with immune infiltrates within tumors based on whole slide images correlated with patient survival in bladder cancer

Background: High tumor mutation burden (TMB-H) could result in an increased number of neoepitopes from somatic mutations expressed by a patient’s own tumor cell which can be recognized and targeted by neighboring tumor-infiltrating lymphocytes (TILs). Deeper understanding of spatial heterogeneity an...

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Bibliographic Details
Main Authors: Hongming Xu, Ph.D., Jean René Clemenceau, Sunho Park, Ph.D., Jinhwan Choi, M.S., Sung Hak Lee, M.D., Tae Hyun Hwang, Ph.D.
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Pathology Informatics
Subjects:
Tumor mutation burden prediction
Computational pathology
Bladder cancer
Survival prognosis
Spatial Heterogeneity
Tumor Immune Microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S215335392200699X

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http://www.sciencedirect.com/science/article/pii/S215335392200699X

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