Construction of a Live-Attenuated Vaccine Strain of Yersinia pestis EV76-B-SHUΔpla and Evaluation of Its Protection Efficacy in a Mouse Model by Aerosolized Intratracheal Inoculation

Construction of a Live-Attenuated Vaccine Strain of Yersinia pestis EV76-B-SHUΔpla and Evaluation of Its Protection Efficacy in a Mouse Model by Aerosolized Intratracheal Inoculation

Plague, which is caused by Yersinia pestis, is one of the most dangerous infectious diseases. No FDA-approved vaccine against plague is available for human use at present. To improve the immune safety of Y. pestis EV76 based live attenuated vaccine and to explore the feasibility of aerosolized intra...

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Bibliographic Details
Main Authors: Junxia Feng, Yingying Deng, Mengjiao Fu, Xueyuan Hu, Wenbo Luo, Zhiyu Lu, Lupeng Dai, Huiying Yang, Xiaodong Zhao, Zongmin Du, Bohai Wen, Lingxiao Jiang, Dongsheng Zhou, Jun Jiao, Xiaolu Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Yersinia pestis
live-attenuated vaccine
aerosolized intratracheal inoculation
mucosal immune
low residual virulence
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00473/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.00473/full

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