Sensitive detection of microRNAs using polyadenine-mediated fluorescent spherical nucleic acids and a microfluidic electrokinetic signal amplification chip

Sensitive detection of microRNAs using polyadenine-mediated fluorescent spherical nucleic acids and a microfluidic electrokinetic signal amplification chip

The identification of tumor-related microRNAs (miRNAs) exhibits excellent promise for the early diagnosis of cancer and other bioanalytical applications. Therefore, we developed a sensitive and efficient biosensor using polyadenine (polyA)-mediated fluorescent spherical nucleic acid (FSNA) for miRNA...

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Bibliographic Details
Main Authors: Jun Xu, Qing Tang, Runhui Zhang, Haoyi Chen, Bee Luan Khoo, Xinguo Zhang, Yue Chen, Hong Yan, Jincheng Li, Huaze Shao, Lihong Liu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Pharmaceutical Analysis
Subjects:
MicroRNAs
Microfluidic chip
Electrokinetic signal amplification
Polyadenine-DNA
Gold nanoparticle
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177922000521

Internet

http://www.sciencedirect.com/science/article/pii/S2095177922000521

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