Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer
The Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway. We summarized the literature on Keap1-Nrf2 signaling pathway and summarized the following...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1381467/full |
| _version_ | 1797226477823983616 |
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| author | Feilong Chen Mei Xiao Shaofan Hu Meng Wang |
| author_facet | Feilong Chen Mei Xiao Shaofan Hu Meng Wang |
| author_sort | Feilong Chen |
| collection | DOAJ |
| description | The Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway. We summarized the literature on Keap1-Nrf2 signaling pathway and summarized the following three aspects: structure, function pathway, and cancer and clinical application status. This signaling pathway is similar to a double-edged sword: on the one hand, Nrf2 activity can protect cells from oxidative and electrophilic stress; on the other hand, increasing Nrf2 activity can enhance the survival and proliferation of cancer cells. Notably, oxidative stress is also considered a marker of cancer in humans. Keap1-Nrf2 signaling pathway, as a typical antioxidant stress pathway, is abnormal in a variety of human malignant tumor diseases (such as lung cancer, liver cancer, and thyroid cancer). In recent years, research on the Keap1-Nrf2 signaling pathway has become increasingly in-depth and detailed. Therefore, it is of great significance for cancer prevention and treatment to explore the molecular mechanism of the occurrence and development of this pathway. |
| first_indexed | 2024-04-24T14:25:32Z |
| format | Article |
| id | doaj.art-44d67c2ce66d47b9b102b1404072b2a8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T14:25:32Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-44d67c2ce66d47b9b102b1404072b2a82024-04-03T04:57:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13814671381467Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancerFeilong Chen0Mei Xiao1Shaofan Hu2Meng Wang3Sports Medicine Key Laboratory of Sichuan Province, Expert Centre of Sichuan Province, Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaCollege of Bioengineering, Chongqing University, Chongqing, ChinaDepartment of Biochemistry and Molecular Biology, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Biochemistry and Molecular Biology, Third Military Medical University (Army Medical University), Chongqing, ChinaThe Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway. We summarized the literature on Keap1-Nrf2 signaling pathway and summarized the following three aspects: structure, function pathway, and cancer and clinical application status. This signaling pathway is similar to a double-edged sword: on the one hand, Nrf2 activity can protect cells from oxidative and electrophilic stress; on the other hand, increasing Nrf2 activity can enhance the survival and proliferation of cancer cells. Notably, oxidative stress is also considered a marker of cancer in humans. Keap1-Nrf2 signaling pathway, as a typical antioxidant stress pathway, is abnormal in a variety of human malignant tumor diseases (such as lung cancer, liver cancer, and thyroid cancer). In recent years, research on the Keap1-Nrf2 signaling pathway has become increasingly in-depth and detailed. Therefore, it is of great significance for cancer prevention and treatment to explore the molecular mechanism of the occurrence and development of this pathway.https://www.frontiersin.org/articles/10.3389/fonc.2024.1381467/fullKeap1Nrf2cancerstructurefunctiontranscriptional regulation |
| spellingShingle | Feilong Chen Mei Xiao Shaofan Hu Meng Wang Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer Frontiers in Oncology Keap1 Nrf2 cancer structure function transcriptional regulation |
| title | Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer |
| title_full | Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer |
| title_fullStr | Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer |
| title_full_unstemmed | Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer |
| title_short | Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer |
| title_sort | keap1 nrf2 pathway a key mechanism in the occurrence and development of cancer |
| topic | Keap1 Nrf2 cancer structure function transcriptional regulation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1381467/full |
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