Attenuation of Hypocretin/Orexin Signaling Is Associated With Increased Mortality After Myocardial Infarction

Attenuation of Hypocretin/Orexin Signaling Is Associated With Increased Mortality After Myocardial Infarction

Background The hypocretin/orexin system has been shown to play a role in heart failure. Whether it also influences myocardial infarction (MI) outcomes is unknown. We evaluated the effect of the rs7767652 minor allele T associated with decreased transcription of the hypocretin/orexin receptor‐2 and c...

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Bibliographic Details
Main Authors: Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Petr Jarolím, Dana Dlouhá, Marek Šramko, Martin Kotrč, Michael Želízko, Jolana Mrázková, Jan Piťha, Věra Adámková, Josef Kautzner
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
hypocretin/orexin receptor‐2
hypocretin/orexin system
inflammation
mortality
myocardial infarction
outcomes
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.028987

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https://www.ahajournals.org/doi/10.1161/JAHA.122.028987

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