Effect of Empagliflozin on Thioacetamide-Induced Liver Injury in Rats: Role of AMPK/SIRT-1/HIF-1α Pathway in Halting Liver Fibrosis

Effect of Empagliflozin on Thioacetamide-Induced Liver Injury in Rats: Role of AMPK/SIRT-1/HIF-1α Pathway in Halting Liver Fibrosis

Hepatic fibrosis causes severe morbidity and death. No viable treatment can repair fibrosis and protect the liver until now. We intended to discover the empagliflozin’s (EMPA) hepatoprotective efficacy in thioacetamide (TAA)-induced hepatotoxicity by targeting AMPK/SIRT-1 activity and reducing HIF-1...

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Bibliographic Details
Main Authors: Marwan A. ElBaset, Rana S. Salem, Fairouz Ayman, Nadeen Ayman, Nooran Shaban, Sherif M. Afifi, Tuba Esatbeyoglu, Mahmoud Abdelaziz, Zahraa S. Elalfy
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
antioxidant
inflammation
cytokines
hepatic fibrosis
caspase-3
Online Access:https://www.mdpi.com/2076-3921/11/11/2152

Internet

https://www.mdpi.com/2076-3921/11/11/2152

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