4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice

4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway during neurodevelopment leads to focal cortical malformations associated with intractable seizures. Recent evidence suggests that dysregulated cap-dependent translation downstream of mTORC1 contributes to cytoarchitect...

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Bibliographic Details
Main Authors: Lena H. Nguyen, Manas Sharma, Angelique Bordey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neuroscience
Subjects:
mTOR
4E-BP
seizures
epilepsy
corticogenesis
cortical development
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1257056/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1257056/full

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