4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice
Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway during neurodevelopment leads to focal cortical malformations associated with intractable seizures. Recent evidence suggests that dysregulated cap-dependent translation downstream of mTORC1 contributes to cytoarchitect...
Main Authors: | Lena H. Nguyen, Manas Sharma, Angelique Bordey |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-08-01
|
Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1257056/full |
Similar Items
-
Regulation of mTORC1 by lysosomal calcium and calmodulin
by: Ruo-Jing Li, et al.
Published: (2016-10-01) -
Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
by: Erin R Cullen, et al.
Published: (2024-03-01) -
mTORC1 signaling in hepatic lipid metabolism
by: Jinbo Han, et al.
Published: (2017-04-01) -
Relationship of mTORC1 and ferroptosis in tumors
by: Huilin Liao, et al.
Published: (2024-04-01) -
Skeletal muscle mTORC1 regulates neuromuscular junction stability
by: Martina Baraldo, et al.
Published: (2020-02-01)