HMGB1/PI3K/Akt/mTOR Signaling Participates in the Pathological Process of Acute Lung Injury by Regulating the Maturation and Function of Dendritic Cells

HMGB1/PI3K/Akt/mTOR Signaling Participates in the Pathological Process of Acute Lung Injury by Regulating the Maturation and Function of Dendritic Cells

Background: High-mobility group box 1 protein (HMGB1) was identified as a highly conserved DNA binding nuclear protein, which participates in the processes of acute lung injury (ALI). HMGB1 binds to its specific receptors not only to activate the nuclear factor (NF)-κB and mitogen-activated protein...

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Bibliographic Details
Main Authors: Ruiting Li, Xiaojing Zou, Haiyan Huang, Yuan Yu, Hongmei Zhang, Pei Liu, Shangwen Pan, Yaqi Ouyang, You Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
HMGB1
PI3K/Akt/mTOR signaling
acute lung injury
lipopolysaccharide
dendritic cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01104/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01104/full

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