Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer
Abstract Radiotherapy is an important modality in lung cancer treatment. Despite advances in treatment planning and dose delivery, patient benefit is still limited by in-field relapse and metastatic recurrence. Simultaneous application of cisplatinum-based chemotherapy leads to moderately improved o...
Main Authors: | Clotilde Thumser-Henner, Sebastian Oeck, Sophie Kalmbach, Jan Forster, Franziska Kindl, Ali Sak, Alexander Schramm, Martin Schuler |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-06-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-022-04978-4 |
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