Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation

Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation

Conflicting evidence suggest that perturbations of GABAergic neurotransmission play crucial roles in disrupting cortical neuronal network oscillations, memory, and cognitive deficits in Alzheimer's disease (AD). However, the role and impact of sex differences on GABAergic transmission in AD are...

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Bibliographic Details
Main Authors: James Auta, Andrea Locci, Alessandro Guidotti, John M. Davis, Hongxin Dong
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Neurobiology
Subjects:
GABA
Diazepam
Alzheimer's
Epigenetics
Behavior
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S2665945X21000218

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http://www.sciencedirect.com/science/article/pii/S2665945X21000218

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