Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes

Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes

Abstract Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) engage (auto)antigens. Here, using a peptide phage d...

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Bibliographic Details
Main Authors: Yun Liu, Chelsea D Higgins, Cathie M Overstreet, Kanti R Rai, Nicholas Chiorazzi, Jonathan R Lai
Format: Article
Language:English
Published: BMC 2013-08-01
Series:Molecular Medicine
Subjects:
Chronic Lymphocytic Leukemia
Immunoglobulin Heavy Chain Diversity (IGHV)
B-cell Receptor (BCRs)
Phage Display Peptide Library
Specific BCRs
Online Access:https://doi.org/10.2119/molmed.2013.00082

Internet

https://doi.org/10.2119/molmed.2013.00082

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