Identification of a Hydrogen-Sulfide-Releasing Isochroman-4-One Hybrid as a Cardioprotective Candidate for the Treatment of Cardiac Hypertrophy

Identification of a Hydrogen-Sulfide-Releasing Isochroman-4-One Hybrid as a Cardioprotective Candidate for the Treatment of Cardiac Hypertrophy

Cardiac pathological hypertrophy is associated with undesirable epigenetic changes and causes maladaptive cardiac remodeling and heart failure, leading to high mortality rates. Specific drugs for the treatment of cardiac hypertrophy are still in urgent need. In the present study, a hydrogen-sulfide-...

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Bibliographic Details
Main Authors: Yu Wang, Yuechen Liu, Hongyu Wu, Shengtao Xu, Fenfen Ma
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
H<sub>2</sub>S donors
cardiac hypertrophy
cardiac fibrosis
AMPK
isochroman-4-one
hybrids
Online Access:https://www.mdpi.com/1420-3049/27/13/4114

Internet

https://www.mdpi.com/1420-3049/27/13/4114

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