miR-33a-3p regulates METTL3-mediated AREG stability and alters EMT to inhibit pancreatic cancer invasion and metastasis

Abstract Recent studies have shown that amphoteric regulatory protein (AREG), a member of the epidermal growth factor (EGF) family, is expressed in many cancers and is an independent prognostic indicator for patients with pancreatic cancer, but whether AREG is regulated at the epigenetic level to pr...

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Bibliographic Details
Main Authors: Xiaowen Su, Tiantian Lai, Yue Tao, Yong Zhang, Changyong Zhao, Junjing Zhou, Enhong Chen, Maoqun Zhu, Shuo Zhang, Bei Wang, Yong Mao, Hao Hu
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39506-7