Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork directionality profiles obtained by RNA-seq, R...

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Bibliographic Details
Main Authors: Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina M Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit, Aloys Schepers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
DNA replication initiation
replication timing
ok-seq, chip-seq
transcription
orc, mcm complex
H4K20 methylation
Online Access:https://elifesciences.org/articles/62161

Internet

https://elifesciences.org/articles/62161

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