DAD3 targets ACE2 to inhibit the MAPK and NF-κB signalling pathways and protect against LPS-induced inflammation in bovine mammary epithelial cells

DAD3 targets ACE2 to inhibit the MAPK and NF-κB signalling pathways and protect against LPS-induced inflammation in bovine mammary epithelial cells

Abstract The protective arm of the renin-angiotensin system (RAS), the ACE 2/Ang-(1–7)/MasR axis, has become a new anti-inflammatory target. As a specific activator of ACE2, diminazene aceturate (DA) can promote anti-inflammatory effects by regulating the ACE2/Ang-(1–7)/MasR axis. However, due to th...

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Bibliographic Details
Main Authors: Xiangjun Zhang, Fang Jia, Weiwu Ma, Xueqiang Li, Xuezhang Zhou
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Veterinary Research
Subjects:
Diminazene aceturate
diminazene aceturate derivative
bovine mammary epithelial cells
angiotensin-converting enzyme 2
inflammation
Online Access:https://doi.org/10.1186/s13567-022-01122-0

Internet

https://doi.org/10.1186/s13567-022-01122-0

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