PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to pre...

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Bibliographic Details
Main Authors: Min Xie, Yan Yu, Rui Kang, Shan Zhu, Liangchun Yang, Ling Zeng, Xiaofang Sun, Minghua Yang, Timothy R. Billiar, Haichao Wang, Lizhi Cao, Jianxin Jiang, Daolin Tang
Format: Article
Language:English
Published: Nature Portfolio 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13280

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https://doi.org/10.1038/ncomms13280

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