PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to pre...
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Bibliographic Details
| Main Authors: |
Min Xie,
Yan Yu,
Rui Kang,
Shan Zhu,
Liangchun Yang,
Ling Zeng,
Xiaofang Sun,
Minghua Yang,
Timothy R. Billiar,
Haichao Wang,
Lizhi Cao,
Jianxin Jiang,
Daolin Tang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13280
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