PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to pre...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13280 |
| _version_ | 1818341787229487104 |
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| author | Min Xie Yan Yu Rui Kang Shan Zhu Liangchun Yang Ling Zeng Xiaofang Sun Minghua Yang Timothy R. Billiar Haichao Wang Lizhi Cao Jianxin Jiang Daolin Tang |
| author_facet | Min Xie Yan Yu Rui Kang Shan Zhu Liangchun Yang Ling Zeng Xiaofang Sun Minghua Yang Timothy R. Billiar Haichao Wang Lizhi Cao Jianxin Jiang Daolin Tang |
| author_sort | Min Xie |
| collection | DOAJ |
| description | Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to prevent sepsis in mice. |
| first_indexed | 2024-12-13T16:04:20Z |
| format | Article |
| id | doaj.art-44e902eea61c43bbab9d4975480e57e9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:04:20Z |
| publishDate | 2016-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-44e902eea61c43bbab9d4975480e57e92022-12-21T23:39:04ZengNature PortfolioNature Communications2041-17232016-10-017111310.1038/ncomms13280PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activationMin Xie0Yan Yu1Rui Kang2Shan Zhu3Liangchun Yang4Ling Zeng5Xiaofang Sun6Minghua Yang7Timothy R. Billiar8Haichao Wang9Lizhi Cao10Jianxin Jiang11Daolin Tang12Department of Pediatrics, Xiangya Hospital, Central South UniversityDepartment of Pediatrics, Xiangya Hospital, Central South UniversityDepartment of Surgery, University of PittsburghCenter of DAMP Biology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pediatrics, Xiangya Hospital, Central South UniversityDepartment of Surgery, University of PittsburghCenter of DAMP Biology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pediatrics, Xiangya Hospital, Central South UniversityDepartment of Surgery, University of PittsburghLaboratory of Emergency Medicine, The Feinstein Institute for Medical ResearchDepartment of Pediatrics, Xiangya Hospital, Central South UniversityState Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Research institute for Traffic Medicine of People’s Liberation Army, Daping Hospital, Third Military Medical UniversityDepartment of Surgery, University of PittsburghInflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to prevent sepsis in mice.https://doi.org/10.1038/ncomms13280 |
| spellingShingle | Min Xie Yan Yu Rui Kang Shan Zhu Liangchun Yang Ling Zeng Xiaofang Sun Minghua Yang Timothy R. Billiar Haichao Wang Lizhi Cao Jianxin Jiang Daolin Tang PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation Nature Communications |
| title | PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation |
| title_full | PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation |
| title_fullStr | PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation |
| title_full_unstemmed | PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation |
| title_short | PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation |
| title_sort | pkm2 dependent glycolysis promotes nlrp3 and aim2 inflammasome activation |
| url | https://doi.org/10.1038/ncomms13280 |
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