The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

Abstract Background HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a novel subset of regulatory T cells, termed follicular regulatory T cells (...

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Bibliographic Details
Main Authors: Bongiwe Mahlobo, Faatima Laher, Werner Smidt, Funsho Ogunshola, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Immunology
Subjects:
Follicular regulatory T cells (TFRs)
Follicular helper T (TFH) cells
Lymph node
Biomarkers
HIV
Online Access:https://doi.org/10.1186/s12865-022-00508-1

Internet

https://doi.org/10.1186/s12865-022-00508-1

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