Reduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome

Reduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome

Background: Dupuytren's disease (DD) is a fibro-proliferative disorder of unknown aetiology. Previous studies have implicated multiple WNT signalling genes/proteins in Dupuytren pathology, including WNT4. However, it is not yet clear whether WNT signalling dysregulation plays an important role...

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Bibliographic Details
Main Authors: Aoife O'Brien, Andrew Stevenson, Lucy Barrett, Nicholas B. Lawler, Nicole Hortin, Zhenjun Deng, Amira Allahham, Fabio Quondamatteo, Nicole Smith, K. Swaminathan Iyer, Fiona M. Wood, Mark W. Fear
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Heliyon
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024140479

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http://www.sciencedirect.com/science/article/pii/S2405844024140479

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