Tumor‐associated macrophages (TAMs)‐derived osteopontin (OPN) upregulates PD‐L1 expression and predicts poor prognosis in non‐small cell lung cancer (NSCLC)

Tumor‐associated macrophages (TAMs)‐derived osteopontin (OPN) upregulates PD‐L1 expression and predicts poor prognosis in non‐small cell lung cancer (NSCLC)

Abstract Background Programmed cell death ligand 1 (PD‐L1) is widely known as an immune checkpoint molecule in tumor cells. Osteopontin (OPN) is expressed by both tumor cells and tumor‐associated macrophages (TAMs), and both autocrine and paracrine of OPN are considered to be involved in tumor metas...

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Bibliographic Details
Main Authors: Yue Li, Hailin Liu, Yujie Zhao, Dongsheng Yue, Chen Chen, Chenguang Li, Zhenfa Zhang, Changli Wang
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Thoracic Cancer
Subjects:
non‐small cell lung cancer (NSCLC)
osteopontin (OPN)
PD‐L1
tumor microenvironment
tumor‐associated macrophages (TAMs)
Online Access:https://doi.org/10.1111/1759-7714.14108

Internet

https://doi.org/10.1111/1759-7714.14108

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